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doi: 10.3390/biomedicines9060602 9 HuhDHamiltonGAIngberDE

Talk with a healthcare professional before starting supplements, as side effects can include abdominal cramps, bloating, and allergic reactions

GSH is synthesized via two ATP-dependent steps: first, -glutamyl cysteine is formed from glutamate and cysteine by -glutamyl cysteine ligase (GCL), the rate-limiting enzyme [9]

RSL3 suppresses spheroid formation and viability, and halts migration of PTC cells in vitro We postulated that the RSL3-mediated suppression of thyroid tumor cell viability is a ferroptosis pathway-dependent process, therefore, we treated K1 cells with a lethal dose of RSL3 alone and in the presence of either a ferroptosis inhibitor Fer1, or a pan caspase inhibitor, Z-VAD-FMK (ZVAD) and measured cell viability