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B12 shots are typically recommended for individuals diagnosed with B12 deficiency or those who may have difficulty absorbing B12 through dietary sources

A 2017 meta-analysis of data from 15 trials, including more than 71,000 participants at risk of or with existing CVD, showed that B-vitamin supplementation had no significant effect on risk of myocardial infarction (heart attack) or all-cause mortality but reduced risk of stroke by 10% (RR, 0.90

When elevated levels are identified, systematic investigation is required to determine the underlying cause

doi:10.1038/ajg.2009.322 81Mackey AC, Green L, Liang L, et al