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The authors thank AI + High Performance Computing Center of ZJU-ICI for their support in molecular dynamics simulations

mito-TEMPO nitroxide radical concentration was obtained by double integration followed by Spin Count module (Bruker) and expressed as the nitroxide radical per g of protein

the aggregating alpha-synuclein also binds preferentially to mitochondria where it can disrupt energy metabolism leading to oxidative stress

These can range from minor issues like bloating, cramping, and allergic reactions, to more severe complications like kidney dysfunction and bronchial constriction, especially in asthmatic individuals