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Safety, tolerability, and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers

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The slow escalation exists specifically because faster titration produces more nausea, more vomiting, and more discontinuations

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Shao X, Wu T, Li M, Zheng M, Lin H, Qi X

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et al., 2023) and colorectal cancer (Xiao et al., 2021

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