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Ten years ago, our group validated this technique to assess esophageal mucosal integrity by showing a correlation to ex vivo measurements and a decrease after esophageal perfusion with acidic solutions (52)

It is a pentadecapeptide , a sequence of 15 amino acids, that is a synthetic analog of a protective peptide naturally occurring in human gastric juice

The latter effect is the result of the reduced ability for platelets to adhere to exposed sub-endothelial extracellular matrix collagen which is required for their activation