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In other embodiments, the concentration of active pharmaceutical ingredient between about 20 and about 80 mM

Numerous studies have reported that inflammation may directly and indirectly affect lung endothelia and pulmonary hemodynamics by activating inflammatory cells, such as neutrophils, macrophages, and lymphocytes, and proinflammatory mediators [13]

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In some embodiments, the syringe comprises a cylindrical syringe body wherein the body is compartmentalized in that each compartment is able to store at least one component of the auris-acceptable otic formulation