Atorvastatin could induce ROS assembling massively in mitochondria, which was partially reduced by ferroptosis inhibitors of DFO, Fer-1 and Lip-1 in HCM (Figures 6A,C) and C2C12 (Figures 6B,D)
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These findings indicate a strong correlation between lipid metabolism and depression, further indicating that targeting lipid metabolism can be a viable approach for preventing and treating depression