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Role of GPx3 in PPAR-induced protection against COPD-associated oxidative stress

Garcia-Mediavilla, M

10.1016/j.tiv.2014.01.004 Toxicol Vitro

Recently, the activation of the JNK pathway by HNE has been shown to occur upstream at the protein tyrosine phosphatase SHP-1that is inhibited by HNE, which also appears to accelerate the degradation of the enzyme (Rinna and Forman, 2008)