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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

BCRP is an ATP-binding cassette efflux transporter in the intestines, kidneys, and liver

Suboptimal or deficient glutathione levels have been associated with various chronic and age-related conditions, including neurodegenerative diseases, mitochondrial dysfunction, and certain types of cancer