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Despite the potential benefits of KD for skin health, randomized clinical trials are needed to evaluate its efficacy and long-term effects, as well as the exact mechanisms by which it affects the skin
doi: 10.1016/j.celrep.2014.06.044 [DOI] [PMC free article] [PubMed] [Google Scholar] 69.Martinod K, Witsch T, Farley K, et al
21 Three clinical trials, one open-label and uncontrolled, 22 one open-label and placebo controlled, 23 and one double-blind and placebo controlled, 24 investigated a multi-nutrient formulation containing NAC 1200 mg per day (other nutrients: folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine and acetyl-L-carnitine) for 312 months in patients with Alzheimers disease, and found significant benefits in Dementia Rating Scale and clock-drawing tests as well as in assessments by caregivers in those receiving the multi-nutrient supplement versus placebo or versus baseline
In addition, risk assessment, technical challenges and a proposed plan for Phase II will be delivered
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