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Serum limitation-induced organ culture model of keloids and apoptotic induction of FOXO4-DRI in situ The keloid tissues were cut into 4-mm diameter cylinders using a corneal trephine for organ culture and cultured in a DMEM containing 2% FBS for 10 days to construct the serum limitation-induced senescent organ culture model of keloid tissues

Detergent removal of mixed micelle is the adsorption technique where detergents (alkyl glycosidase, Triton X-100, cholate) are kept in a shaking condition with beads of adsorbers functionalized on micelles

Reconstitution & Handling Each 5 mg vial is typically reconstituted with 2 mL of bacteriostatic water, yielding a 2.5 mg/mL working stock, though investigators may adjust volumes based on study design and dosing precision needs

The products which have changed are not injectable