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Description

In vitro tests also demonstrated that malassezin is not a tyrosinase inhibitor, but a highly active agonist of the aryl hydrocarbon receptor with key homeostasis functions that may impact the mechanism of pigmentation

Research suggests it participates in detoxification, peroxide reduction, and redox signaling by serving as a cofactor for glutathione-dependent enzymes

3c), compounds 1 - 5 were found to be slow inhibitors as they displayed little to no inhibition after 15 min, but time-dependent inhibition of TGR over 25 h (Fig