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S., Fontana, W

Similar phenotypes were observed between HMEC-1 cells and Vero cells, including defects in cell division and actin-based motility upon GSH depletion (Fig

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The reduced lysosome function appears multifactorial but includes direct and indirect inhibition of lysosomal acid lipase, the enzyme responsible for hydrolysis of cholesteryl esters in lysosomes, and a reduced capacity for transferring cholesterol from lysosomes (159-162)