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After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs

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In the STEP1 involved 1,961 participants with obesity or overweight, 68-week treatment of semaglutide 2.4 mg demonstrated an average weight reduction of 14.9% [16]