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Es greift nicht in die Hormonregulation ein, verndert nicht die Iris-Pigmentierung und steht nicht im Zusammenhang mit Reizungen oder Lidverdunkelung, wie sie bei hochdosierten Prostaglandinen beschrieben sind

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Although the initial results with portosystemic shunts may be beneficial, the long-term outcome for patients who require shunts is poor because these patients usually have severe SOS and intervention generally delays, but does not prevent, a fatal outcome

By the time someone reaches their maintenance dose, many of the early GI issues have resolved or become much more manageable