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The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

However, 3.3% (Week 4), 10.0% (Week 6), 20.0% (Week 8), and 30.0% (Week 10) of subjects gave a wrinkle-reduction score of 2 to GSSG sites

A growing body of evidence supports a consideration that tetratricopeptide repeat proteins with carboxylate clamps are also required for a normal HSP70HSP90 interaction, bringing both of them geometrically closer to client proteins (Pokhrel et al., 2025)

Am J Trop Med Hyg 104:20652068