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This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression

In topical application studies, no significant adverse effects have been reported

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Thus, ozone therapy can be a new therapeutically approach for atopic asthma thanks to its immunomodulation and oxidative stress regulation properties