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Consistent with the toxicity of isoniazid in slow acetylators, there is an increased incidence of other drug toxicities in subjects carrying defective alleles, such as lupus erythematosus in patients treated with hydralazine or procainamide (Sim et al., 1988), and haemolytic anemia and inflammatory bowel disease after treatment with sulfasalazine (Chen et al., 2007)

Since peroxiredoxins are the main reductases for different hydroperoxides such as H 2 O 2 and peroxynitrite, persulfidation would cause an increase in cellular steady-state levels of these oxidants

c-capase-3, -8, -9, Cleaved capase-3, -8, -9, Malondialdehyde (MDA)