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This arrangement presumably prevents the electrostatic repulsion of the two glutathione moieties on the surface of active glutaredoxins

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It is known to exacerbate inflammation and redox imbalances (251) by triggering the NLR family pyrin domain containing 3 (NLRP3) inflammasome (251), increasing the release of inflammatory cytokines such as IL-1 and IL-18 (376)

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