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Taken together, these results indicate that expanding h-HepOrgs in EM2 may represent an immature hepatocyte state

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This is also consistent with our recent work showing that different ITCs lead to various degree of growth inhibition depending on their side chain structure 74

GHK-Cu has a molecular weight of approximately 341 daltons, making it borderline permeable topically, but its copper chelation and charge state at physiological pH reduce actual transdermal flux substantially