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Route of Delivery Matters for Timeline Transdermal estrogen (patches, gels, creams): Produces steadier blood levels Often leads to smoother symptom improvement Oral formulations: Undergo liver metabolism May take longer to stabilize Delivery method selection influences how improvements unfoldnot just if they occur

[23] Activation of MT2 receptors in the suprachiasmatic nucleus can shift the timing of the circadian clock, either advancing or delaying the sleep-wake cycle depending on the timing of melatonin administration

Moreover, typical CysGPXs share a similar catalytic cycle to 2-Cys PRXs and are hypothesised to function in the same way 54,73 (Fig