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Typical patterns include: Rapid initial loss (first 4-6 weeks), much of which is water and glycogen Steady loss during mid-protocol (weeks 6-24) Plateaus lasting 1-3 weeks that resolve spontaneously Slower deceleration as you approach new equilibrium weight If you hit a plateau on tirzepatide that persists beyond 4-6 weeks at maximum dose, the tirzepatide troubleshooting guide covers the most common causes and solutions

Over time, if left untreated, pernicious anemia can cause severe complications such as nerve damage, cognitive problems, and heart issues

10.1038/s41419-019-1678-y 205 TullyD

Matern Child Nutr 10(3):327334