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Finally, we emphasize the potential and personalized implementation pathways of synergistically integrating microbiota modulation with existing therapies such as antivirals, antifibrotics, immunotherapy, and metabolic surgery

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Future studies systematically exploring sex- and gender-based differences in eCB function and related behaviors will be critical in determining the translational validity of these findings and subsequently developing novel pharmacotherapies more broadly

Metabolic and Immune Support Beyond its antioxidant role, glutathione is necessary for healthy carbohydrate metabolism and is involved in metabolizing insulin and regulating blood glucose levels already in the normal range