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This is where supplementation may help

Higher levels of HDL are associated with a lower risk of heart disease, as it helps prevent cholesterol buildup in arteries

The current gold-standard approach to assess metabolite interactions in such cases is isotopic labeling, which allows the tracking of one or more heavy elemental isotopes through the metabolome with mass spectrometry, nuclear-magnetic resonance, or similar metabolomic techniques (Wang et al., 2024)