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In HCC, SHMT2 knockdown increases the sensitivity of hepatocellular carcinoma cells to doxorubicin [183]

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NADPH also acts as a cofactor for glutathione reductase, the enzyme used to maintain reduced glutathione (GSH) levels by converting its oxidized form, glutathione disulfide (GSSG), back to GSH.[1] NAD(H) and ATP Production The NAD molecule, whether as NAD(H) or NADP(H) is involved in cellular and mitochondrial redox reactions