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The 4.5 mg dose produced 10.8% reduction (11.5 kg average)

If the underlying disease process has resolved and cobalamin body stores have been replenished, serum cobalamin concentration should be supranormal [higher than normal] at the time of reevaluation

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The dual agonist mechanism provides robust glycemic control and significant weight reduction, with clinical trials demonstrating A1C reductions of 1.92.4% and weight loss of approximately 1522% of body weight in non-diabetic adults with obesity (SURMOUNT-1 trial), with more modest weight loss typically observed in patients with type 2 diabetes