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J Agric Food Chem 56(22):1056710573

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Multiple studies have demonstrated that consistent administration of HCQ and CQ during the first five years of the disease improves treatment outcomes, whether used as monotherapy or in combination with other therapies (104)

Consistent with this, a clinical trial investigating oral butyrate supplementation in rat models of colitis demonstrated a significant reduction in messenger RNA expression of pro inflammatory cytokines such as interleukin 6, tumor necrosis factor alpha, and interleukin 1 beta, together with inhibition of mitochondrial reactive oxygen species production (58)