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Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels

Peripheral Neuropathy is changes to the sensory nerves and in some cases the motor nerves can also be affected

By inhibiting NNMT activity, 5-Amino-1MQ modulates enzymatic processes associated with nicotinamide metabolism, methylation network regulation, and intracellular cofactor-associated signaling systems

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