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Generally, these variation peptides are found in parts per million in active technologies that topical products claim to include at high percentages but the final concentration of the variation peptides in topical products is generally less than 0.01% and these peptides would then have to be converted to even smaller amounts of pure copper peptides within the skin

For a bulk drug substancethe raw Active Pharmaceutical Ingredient (API)to be legally compounded under Section 503A, it must possess an official USP/NF Monograph, be a component of an FDA-approved drug, or appear on the FDAs Bulks List as Category 1

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661 Even then, metal binding site promiscuity and a lack of sensitivity can limit the use of naturally occurring metalloregulators for a particular application