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Samples were alkylated with 20 mM iodoacetamide (IOA) and incubated at room temperature for 1 h in the dark before the reaction was quenched with 2.5 mM dithiothreitol (DTT) and diluted to 0.1% SDC in 50 mM triethylammonium bicarbonate (TEAB) prior to proteolytic digest

In addition, we calculated the highest occupied molecular orbital (HOMO) energy on TAM and its metabolites, which can inflict oxidative DNA damage

However, some of the key players are targeting to acquire the startup companies in order to maintain their dominance in the global market

Hautala et al ., Reference Hautala, Pursiainen, Nreaho, Nyman, Varmanen, Sukura, Nielsen and Savijoki2022)