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For most people: Nicotine itself is detectable for about 13 days Cotinine is detectable for about 34 days In heavy or frequent users, cotinine may be detectable for up to 710 days The detection window depends on several factors, including: Frequency of vaping Nicotine strength of the vape product Metabolism Hydration levels Liver function Body composition Someone who vapes occasionally may clear cotinine faster than someone who vapes daily

Moreover, the ASSISTs evaluation criteria correspond with the DSM-5s 11 diagnostic criteria for substance use disorders, which include factors such as impaired control, social impairment, risky use, and pharmacological indicators like tolerance and withdrawal

It is possible that upon cisplatin treatment, nicotine specifically affects a particular residue of Bcl-2 that timely controls the process of ubiquitination

R., Copeland, J., Moeller, S