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Description

Wang et al., 2020b, 2019a

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doi: 10.1038/nm.2962 113 van der ZandeHJPGonzalezMAde RuiterKWilbersRHPGarca-TardnNvan HuizenMet al

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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

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Long-term controlled safety data are absent

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